Detaillierte Beitrags-Information

Zurück zur Liste

Beitragstitel Intra-Observer Reproduzierbarkeit von OCT-A Gefässdichte-, Perfusions- und Foveale-avaskuläre-Zone-Messungen bei Patienten mit nicht-proliferativer diabetischer Retinopathie und in einer Kontrollgruppe
Autor:innen
  1. Menke Marcel Kantonsspital Aarau AG Präsentierende:r
  2. Arthur Baston Universitätsspital Basel
  3. Stefan Trachsler Kantonsspital Aarau AG
Präsentationsform ePoster
Themengebiete
  • Retina Vitreous
Abstract-Text Purpose:
To test intra-observer reproducibility of OCT-A vessel density-, perfusion-, and foveal avascular zone measurements in patients with non-proliferative diabetic retinopathy and in healthy controls

Methods:
Twenty-six eyes of 13 healthy controls and 20 eyes of 10 patients with non-proliferative diabetic retinopathy (DR) in both eyes have been included. Zeiss Cirrus 5000 OCT-A Angioplex was used to measure retinal vessel density, perfusion and foveal avascular zone (FAZ) areas. One examiner repeated 3 measurements of each eye in one session. Volume scans of 6x6mm were used to allow calculation of mean values using an ETDRS grid overlay. Intraclass correlation coefficients (ICC) have been calculated to test reproducibility. In addition differences between groups were analyzed.

Results:
Mean vessel density values were significantly lower in patients with DR compared to controls in all tested ETDRS areas (central, inner ring, outer ring, full area, p-values ranged between < 0.001 to 0.008). Perfusion was significantly lower in DR patients for the central area (p=0.006), the outer ring (p=0.001), and the whole area (p=0.003). FAZ area and perimeter were significantly larger in DR patients (p= < 0.001 and 0.009, respectively). FAZ circularity was less in DR patients (p < 0.001). ICCs ranged from 0.95 to 0.986 for vessel density in controls and from 0.779 to 0.859 in DR patients. For perfusion, ICCs ranged from 0.95 to 0.987 in controls and from 0.77 to 0.834 in DR patients. For FAZ measurements (area, perimeter, and circularity) ICCs ranged from 0.869 to 0.95 in controls and 0.182 to 0.592 in DR patients.

Conclusion:
Patients with non-proliferative DR showed significantly lower OCT-A vessel density and perfusion values for most ETDRS areas. FAZ area and perimeter were significantly greater in DR patients. The reproducibility for such measurements was excellent except for FAZ measurement in DR eyes.